FREE UK Delivery | Orderline: 01279 510 552

FREE UK DELIVERY

60 DAY MONEY BACK GUARANTEE

AVAILABLE IN CLINICS & SALONS

Liquid Joint Supplement

CARTONICA

£29.95

In stock     Free Delivery

Cartonica is the nutrient-packed liquid joint supplement which beats all tablets for range and quantity of nutrients.

  • Over 6,000mg of nutrients per serving
  • Glucosamine, Chondroitin + Collagen, Vit D & MSM
  • Liquid for efficient nutrient absorption
  • Delicious berry flavour
  • 33 day supply per bottle
PayClear
  • VISA
  • Mastercard
  • Masestro
  • PayPal
  • Apple Pay
  • Google Pay
SKU: N/A Category:

Customer Reviews

Based on 4 reviews
100%
(4)
0%
(0)
0%
(0)
0%
(0)
0%
(0)
D
Dennis Wells
Works For Me

Been using for about 18 months and seems to keep my joints healthy and pain free, would prefer it a little less sweet though.
Easy to order with reliable delivery or get on subscription for regular delivery.

F
Fullwood
Great stuff!

We use this regularly and find it helps so much. We recommend it to everyone.

J
Julie Buxton
Superb & very tasty.

Arrived on time and a great product. Taste good too.

C
Customer
Cartonica Really Helps

I have been taking Cartonica for a few months. Like the taste but more importantly, helps my knees. Good service, many thanks.

Cartonica is the liquid joint supplement used by professionals which is changing the way people take joint supplements.

As it’s a liquid, the nutrients are dissolved meaning Cartonica has far more nutrients from a single serving than any tablet joint supplement:

  • Collagen Type II
  • Glucosamine, Chondroitin, MSM
  • L-Carnitine & Turmeric
  • Vit C, B12 and D

The smooth cartilage surfaces of our joints consist mainly of  collagen.  90-95% of the collagen is type II and Cartonica has five times more type II collagen than any tablets.

All of the nutrients in Cartonica are fully supported by scientific references (see ingredients tab).

Beats All Tablets

Tablet joint supplements can only contain a limited quantity of nutrients, typically a maximum of 1,000mg per tablet.

Practically all traditional glucosamine and chondroitin joint supplements require us to take two or even three tablets per day.  Despite that, even then the nutritional content and number of nutrients in those tablets falls well short of what is contained in Cartonica.

There are hundreds of different joint supplements to choose from and it can be very confusing for patients to know what to take.

Liquid nutrition allows us to dissolve the nutrients and as a liquid, the nutrients are easily absorbed by the body.

With 10 nutrients per serving in Cartonica, more than any joint supplement tablet, the choice of supplement hopefully becomes straightforward.

Cartonica has over 6,000mg of nutrients  per serving which includes five times more type II collagen than joint tablet supplements.  

Cartonica Highlights

  • Collagen Type II is a protein made from amino acids. It accounts for 60% of the dry weight of joint cartilage. Type II collagen represents 90-95% of the total collagen in joints. The body uses amino acids and nutrients to make collagen and cartilage in joints.
  • Glucosamine Sulphate is present in the fluid which provides lubrication around joints and is a building block of cartilage.
  • Chondroitin Sulphate is a component of cartilage which retains water and is intended to enhance shock-absorbing properties.
  • MSM (Methylsulfonylmethane) contains sulphur, a building block for complex proteins called glycosaminoglycans which are in the structure of cartilage.
  • L-Carnitine is converted in the body to acetyl-L-carnitine (ALC). ALC helps maintain cell energy and protects against oxidative damage.

Cartonica also contains Vitamin C which helps the body form and repair cartilage, Vitamin D which allows the body to absorb calcium from our blood stream to make bone and Turmeric which is regarded as a natural anti-inflammatory.  See label for nutrient list.

When to Take Cartonica

Most people drink Cartonica at or before breakfast.  Each bottle comes with a handy measuring cap and you can drink Cartonica neat or diluted with water.  Whatever suits you best.

It has a delicious berry flavour and for people who don’t like taking tablets especially, this is a reason to choose Cartonica in itself.

Each bottle of Cartonica is 500ml which represents a 33 day supply and it can be taken with Vitaliti and/ or Cutizana.  Once opened, just keep in the fridge.

Money Back Guarantee

We offer a 60 day money back guarantee on single bottles. That allows you to take Cartonica for one month and have time in the unlikely event you feel it has not helped you to let us know.

The guarantee is on single bottle purchases, the return rate is under 1%.

About Clinic Nutrition

At Clinic Nutrition we aim to simplify the choice for you by delivering nutrient-packed, delicious tasting supplements that are a pleasure to take, without ever being over-priced to match a hype.

We supply liquid supplements to medical clinics and hair and beauty centres.

Allergen advice: Glucosamine from shellfish extract.
Not suitable for vegetarians. Type II collagen from bovine extract.

Cartonica nutrients supporting joint health

Below is a description of each ingredient in the Cartonica blend, their purpose in joint health along with references to published studies.

  • Vitamin B12

Vitamin B12 or cobalamin is a water-soluble vitamin that plays a key role in various physiological functions. For example, healthy production of red blood cells, maintenance of nerve function and proper regulation of mood.

In addition, it also supports joint health in two ways; first, lowers the risk of bone fracture,  second, it helps normalise homocysteine levels, which may be increased in patients with joint disease. (1,2)

  • Vitamin C

Vitamin C or ascorbic acid is a water-soluble vitamin with powerful antioxidant properties. It binds to the harmful chemical species called free radicals and counteracts their negative effects.

Human studies have shown that vitamin C helps prevent cartilage loss and slows down the progression of joint diseases. (3,4)

  • Vitamin D3

Vitamin D3 or cholecalciferol is a fat-soluble vitamin. It is key to maintaining optimal bone health as it helps your body absorb calcium and phosphorus from your diet.

It helps prevent bone loss by preventing the breakdown of bone tissues and subsequent release of calcium into the bloodstream. In addition, vitamin D supplementation (either oral or using an injection) increases bone mass and reduces the risk of falls. (5,6)

  • Turmeric

Turmeric is a spice of the ginger family. It contains a powerful anti-inflammatory and antioxidant known as curcumin.

Turmeric is a safe and highly effective natural treatment for several joint diseases. Curcumin improves joint tenderness and swelling. It reduces inflammation by blocking the activity of pro-inflammatory substances, prevents cartilage degradation, and counteracts cellular damages. (7,8)

  • Green Tea Extract

Green tea extract is a rich source of potent antioxidants, polyphenols. While green tea extract is sometimes used in weight loss programmes, one of the polyphenols, epigallocatechin-3 gallate (EGCG), has been shown to be beneficial for joint health.

EGCG helps prevent and alleviate the symptoms of joint disease through its anti-inflammatory activity. It works by blocking the activity of inflammatory substances in the cells of cartilage. (9)

  • Hydrolysed Collagen Type II

Hydrolysed collagen type II has been widely studied as a potential treatment for various joint health conditions.

Naturally-occurring type II collagen is a major component of joint cartilage. Joint diseases such as autoimmune arthritis cause a gradual loss of collagen type II and proteoglycans. This results in pain, tenderness, stiffness, and limited mobility. (10)

Laboratory study shows that administration of hydrolysed collagen type II to the culture medium stimulates the production as well as secretion of type II collagen in cartilage tissues. Moreover, ingested hydrolysed collagen type II accumulates in cartilage where it stimulates the synthesis of macromolecules that are necessary for maintaining proper functioning of the joints. (11,12)

  • Glucosamine Sulphate

Glucosamine is a naturally-occurring amino acid that plays a key role in the growth and repair of joint cartilage.

Oral glucosamine sulphate once daily for three years is found to be effective in improving the symptoms of osteoarthritis (OA). (13)

While the exact mechanism behind the benefits of glucosamine is yet to be discovered, scientists believe that it might help maintain joint health by stimulating the production of macromolecules in cartilage and blocking the effects of inflammatory substances. (14)

  • Chondroitin Sulphate

Chondroitin sulphate or Chondroitin Polysulphate is a naturally-occurring substance in joint cartilage. It is necessary for maintaining the resistance and elasticity of cartilage.  It is usually given in combination with glucosamine sulphate.

Chondroitin supplementation has been studied and is believed to help joints by one or more of the (15,16,17,18)

  • Stabilises the joint space and modifies bone metabolism in the joints.
  • Inhibits the destruction of cartilage tissues in the joints.
  • Regulates the synthesis of hyaluronan, a substance that lubricates and cushions the joints.
  • Reduces the production of pro-inflammatory substances in the joints.
  • L-Carnitine

L-carnitine is an amino acid that is naturally found in the body. The body converts ingested L-carnitine into acetyl-L-carnitine, which prevents cartilage degradation and helps reduce pain associated with degenerative joint diseases such as osteoarthritis. (19)

It appears to work primarily by reducing the serum levels of pro-inflammatory substances. (20)

  • Methylsulfonylmethane (MSM)

Methylsulfonylmethane or dimethyl sulfone is an organosulphur compound naturally found in the body. It has antioxidant and anti-inflammatory properties.

As a supplement MSM has been shown to be effective in relieving joint pain and improving the functions of the joints. Interestingly, it is thought that the benefits are increased if using MSM with collagen type II. (21,22)

The beneficial effects of MSM on joint health are believed to be due to its powerful anti-inflammatory property. In addition, it might also decrease cartilage degeneration in the joints. (23,24)

References

  1. Dhonukshe-rutten RA, Pluijm SM, De groot LC, Lips P, Smit JH, Van staveren WA. Homocysteine and vitamin B12 status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people. J Bone Miner Res. 2005;20(6):921-9.
  2. Kuzminski AM, Del giacco EJ, Allen RH, Stabler SP, Lindenbaum J. Effective treatment of cobalamin deficiency with oral cobalamin. Blood. 1998;92(4):1191-8.
  3. Chang Z, Huo L, Li P, Wu Y, Zhang P. Ascorbic acid provides protection for human chondrocytes against oxidative stress. Mol Med Rep. 2015;12(5):7086-92.
  4. Mcalindon TE, Jacques P, Zhang Y, et al. Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis?. Arthritis Rheum. 1996;39(4):648-56.
  5. Sunyecz JA. The use of calcium and vitamin D in the management of osteoporosis. Ther Clin Risk Manag. 2008 Aug; 4(4): 827–836.
  6. Harwood RH, Sahota O, Gaynor K, Masud T, Hosking DJ. A randomised, controlled comparison of different calcium and vitamin D supplementation regimens in elderly women after hip fracture: The Nottingham Neck of Femur (NONOF) Study. Age Ageing. 2004;33(1):45-51.
  7. Chandran B, Goel A. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res. 2012;26(11):1719-25.
  8. Henrotin Y, Priem F, Mobasheri A. Curcumin: a new paradigm and therapeutic opportunity for the treatment of osteoarthritis: curcumin for osteoarthritis management. Springerplus. 2013; 2: 56.
  9. Singh R, Ahmed S, Islam N, Goldberg VM, Haqqi TM. Epigallocatechin-3-gallate inhibits interleukin-1beta-induced expression of nitric oxide synthase and production of nitric oxide in human chondrocytes: suppression of nuclear factor kappaB activation by degradation of the inhibitor of nuclear factor kappaB. Arthritis Rheum. 2002;46(8):2079-86.
  10. Eyre D. Collagen of articular cartilage. Arthritis Res. 2002;4(1):30-5.
  11. Oesser S, Seifert J. Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen. Cell Tissue Res. 2003;311(3):393-9.
  12. Bello AE, Oesser S. Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: a review of the literature. Curr Med Res Opin. 2006;22(11):2221-32.
  13. Reginster JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet. 2001;357(9252):251-6.
  14. Henrotin Y, et al. Physiological effects of oral glucosamine on joint health: current status and consensus on future research priorities. BMC Res Notes. 2013; 6: 115.
  15. Uebelhart D, Thonar EJ, Delmas PD, Chantraine A, Vignon E. Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: a pilot study. Osteoarthr Cartil. 1998;6 Suppl A:39-46.
  16. Jomphe C, Gabriac M, Hale TM, et al. Chondroitin sulfate inhibits the nuclear translocation of nuclear factor-kappaB in interleukin-1beta-stimulated chondrocytes. Basic Clin Pharmacol Toxicol. 2008;102(1):59-65.
  17. David-raoudi M, Deschrevel B, Leclercq S, Galéra P, Boumediene K, Pujol JP. Chondroitin sulfate increases hyaluronan production by human synoviocytes through differential regulation of hyaluronan synthases: Role of p38 and Akt. Arthritis Rheum. 2009;60(3):760-70.
  18. Chou MM, Vergnolle N, Mcdougall JJ, et al. Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis. Exp Biol Med (Maywood). 2005;230(4):255-62.
  19. Bianchi E, Di cesare mannelli L, Menicacci C, Lorenzoni P, Aglianò M, Ghelardini C. Prophylactic role of acetyl-l-carnitine on knee lesions and associated pain in a rat model of osteoarthritis. Life Sci. 2014;106(1-2):32-9.
  20. Malek mahdavi A, Mahdavi R, Kolahi S. Effects of l-Carnitine Supplementation on Serum Inflammatory Factors and Matrix Metalloproteinase Enzymes in Females with Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. J Am Coll Nutr. 2016;35(7):597-603.
  21. Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthr Cartil. 2006;14(3):286-94
  22. Xie Q, Shi R, Xu G, Cheng L, Shao L, Rao J. Effects of AR7 Joint Complex on arthralgia for patients with osteoarthritis: results of a three-month study in Shanghai, China. Nutr J. 2008;7:31.
  23. Butawan M, Benjamin RL, Bloomer RJ. Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement. Nutrients. 2017 Mar; 9(3): 290.
  24. Ezaki J, Hashimoto M, Hosokawa Y, Ishimi Y. Assessment of safety and efficacy of methylsulfonylmethane on bone and knee joints in osteoarthritis animal model. J Bone Miner Metab. 2013;31(1):16-25.